Specifications
Encoded by the PARK2 gene, the E3 ligase Parkin is part of the multi-protein E3 complex that encodes substrate proteins for degradation in the Ubiquitin-Proteosome Pathway. The precise function of this protein is unknown; however, mutations in this gene are known to cause a familial form of Parkinson’s disease known as autosomal recessive juvenile Parkinson’s disease (AR-JP). Parkin is described to be necessary for mitophagy (autophagy of mitochondria).
Product Information
| Purity: | > 95% by SDS-PAGE |
| Molecular Weight: | 51.6 Da |
| Physical State: | Liquid, 50 mM Tris, pH 7.5, 0.15 M NaCl, 10% Glycerol |
| Quantity: | 25 µg |
| Storage: | -80o C. Avoid repeated freeze/thaw cycles |
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