UB318: Untagged Parkin E3 Ligase

Encoded by the PARK2 gene, the E3 ligase Parkin is part of the multi-protein E3 complex that encodes substrate proteins for degradation in the Ubiquitin-Proteosome Pathway. The precise function of this protein is unknown; however, mutations in this gene are known to cause a familial form of Parkinson’s disease known as autosomal recessive juvenile Parkinson’s disease (AR-JP). Parkin is described to be necessary for mitophagy (autophagy of mitochondria).

Product Information

Purity:	> 95% by SDS-PAGE
Molecular Weight:	51.6 Da
Physical State:	Liquid, 50 mM Tris, pH 7.5, 0.15 M NaCl, 10% Glycerol
Quantity:	25 µg
Storage:	-80o C.  Avoid repeated freeze/thaw cycles