UB201: UBE2D3 (UbcH5c)

LifeSensors UB201 is UBE2D3 (UbcH5c), an E2 ubiquitin-conjugating enzyme used in ubiquitination research, supplied at 40 µM concentration for protein regulation studies.

$294.00 – $393.00

SKU UB-0201 Categories E2 Ubiquitin Conjugating Enzymes, Ubiquitin Ligases and Enzymes

Product Advantages

Identify cognate E2/E3 pairs

Characterize upregulation/downregulation of E2 enzymes

Build poly-ubiquitin chains

Characterize ubiquitin chain specificity of E2 enzymes

Analyze expression of E2 enzymes

Benefits

Untagged (native) E2 conjugation enzyme

UBE2D3 is an E2 conjugation enzyme that is involved in the ubiquitylation of target substrates, along with E1 and E3 enzymes. The UbcH5 family (including UbcH5a and UbcH5b, 88% and 89% sequence identity with UbcH5c, respectively) are the human homologues of the Sacchromyces cerevisiae UBC4/5 family (~79% sequence identity). Members of the UbcH5 family have been implicated in a number of inflammatory and cancer pathways including the ubiquitylation of p53 and IκBα with the help of different E3 ligases (Hdm2 and SCF complexes respectively).

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	16,687.2 Da
Quantity	0.8 nmol, 3.0 nmol
Concentration	40 µM
Formulation	25 mM Tris pH 7.5, 150 mM NaCl, 10 mM DTT, 10% glycerol
Storage	-80°C, avoid freeze/thaw cycles