UBE2D3 is an E2 conjugation enzyme that is involved in the ubiquitylation of target substrates, along with E1 and E3 enzymes. The UbcH5 family (including UbcH5a and UbcH5b, 88% and 89% sequence identity with UbcH5c, respectively) are the human homologues of the Sacchromyces cerevisiae UBC4/5 family (~79% sequence identity). Members of the UbcH5 family have been implicated in a number of inflammatory and cancer pathways including the ubiquitylation of p53 and IκBα with the help of different E3 ligases (Hdm2 and SCF complexes respectively).
|Molecular Weight||16,687.2 Da|
|Quantity||0.8 nmol, 3.0 nmol|
|Formulation||25 mM Tris pH 7.5, 150 mM NaCl, 10 mM DTT, 10% glycerol|
|Storage||-80°C, avoid freeze/thaw cycles|