UB228H: UBE2I, His6

This E2 is a SUMO-conjugating enzyme, also known as Ubc9. UBE2I can mediate the transfer of SUMO1, SUMO2, SUMO3, and SUMO4 from SUMO-activating enzyme E1 (UBLE1A-UBLE1B complex) to a substrate protein. This E2 enzyme has been shown to associate with the SUMO E3 ligases, RANBP2 or CBX4. This E2 conjugating enzyme is necessary for sumoylation and it is essential for nuclear architecture and chromosome segregation.

Info

Species	Human
Source	E. coli
Tag	His6
Molecular Weight	18565.3 Da
Quantity	0.8 nmol, 3.0 nmol
Concentration	40 µM
Formulation	50 mM Tris pH 7.5, 150 mM NaCl, 10 mM DTT, 10% glycerol
Storage	-80°C, avoid freeze/thaw cycles