Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9830: MLN-4924

LifeSensors SI9830 (MLN4924) is a potent, selective substrate-assisted inhibitor of NEDD8-activating enzyme (NAE), used to block neddylation and study protein degradation pathways in drug discovery and cancer research.

$231.00

In stock

In stock

Containing the active ingredient of MLN4924 which acts as a substrate-assisted inhibitor of the NEDD8-activating enzyme (NAE). NAE activates NEDD8 (Neural precursor cell expressed, developmentally down-regulated 8) for conjugation to a variety of ubiquitin E3 ligases. NEDD8-MLN4924 adducts bind and inhibit NAE, which may result in the inhibition of tumor cell proliferation and survival. This cell-permeable compound selectively inhibits NAE activity and results in inhibition of the NEDD8 pathway.

Info

Purity >98% (TLC), NMR (conforms)
Quantity 1 mg
Molecular Weight 443.2 Da
Physical State White powder
Solubility DMSO (10 mg/ml)
CAS No. 905579-51-3
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

Applications

  • Inhibition of NEDD8-dependent pathways.
  • Benefits: cell-permeable

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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