SI9830: MLN-4924

LifeSensors SI9830 (MLN4924) is a potent, selective substrate-assisted inhibitor of NEDD8-activating enzyme (NAE), used to block neddylation and study protein degradation pathways in drug discovery and cancer research.

$231.00

SKU SI-9830-0001 Categories E1-E2-E3 Inhibitors, Small Molecule Modulators and PROTACs

In stock

Product Advantages

Applications

Inhibition of NEDD8-dependent pathways.

Benefits: cell-permeable

Containing the active ingredient of MLN4924 which acts as a substrate-assisted inhibitor of the NEDD8-activating enzyme (NAE). NAE activates NEDD8 (Neural precursor cell expressed, developmentally down-regulated 8) for conjugation to a variety of ubiquitin E3 ligases. NEDD8-MLN4924 adducts bind and inhibit NAE, which may result in the inhibition of tumor cell proliferation and survival. This cell-permeable compound selectively inhibits NAE activity and results in inhibition of the NEDD8 pathway.

Info

Purity	>98% (TLC), NMR (conforms)
Quantity	1 mg
Molecular Weight	443.2 Da
Physical State	White powder
Solubility	DMSO (10 mg/ml)
CAS No.	905579-51-3
Storage	4°C, (-20°C Long term). The product can be shipped at room temperature.