SI6303P: K63-Linked Tri-Ubiquitin (Phosphorylated)

SKU SI-6303P-0025 Categories All, Ubiquitin and Neuro-degeneration, Ubiquitin Chains, Ubiquitin Chains and Derivatives, Ubiquitin Derivatives

LifeSensors’ SI6303P is human K63-linked tri-ubiquitin, phosphorylated, produced in E. coli, ideal for studying ubiquitin signaling and protein regulation in research

$695.00

K63 chains traditionally play a role in intracellular signalling, trafficking, and autophagy. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. K63 Tri-Ubiquitin (phosphorylated) is a trimeric chain of wild-type ubiquitin, wherein ubiquitin monomers are linked together via an isopeptide bond between Lysine 63 and the C-terminal Glycine. The chains are then enzymatically phosphorylated at the Ser65 position. Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	25766-25926 Da (depending on degree of phosphorylation)
Quantity	25µg
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Investigation of phospho-ubiquitin chain specificity and selectivity
Studies on the role of phospho-ubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
Analysis of phospho-ubiquitin-mediated signaling pathways and cellular responses
Structural studies to elucidate the architecture and dynamics of phospho-ubiquitin chains

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SI6303P: K63-Linked Tri-Ubiquitin (Phosphorylated)

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