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DUB-resistant, K11-linked Di-ubiquitin (Ub2) contains an amino acid substitution near the C-terminus of the distal ubiquitin that renders it resistant to deubiquitylases (DUBs). DUB-resistant ubiquitin chains are ideal reagents for structural or binding studies with deubiquitylases or other ubiquitin binding proteins. They can also be used as inhibitors or to determine the linkage-specificity of DUBs. The product contains a wild-type C-terminus on the proximal ubiquitin.
|20 mM Tris pH 7.5, 150 mM NaCl, 1 mM EDTA
|-80°C, avoid freeze/thaw cycles