SI4804: K48-Linked Tetra-Ubiquitin


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Poly-ubiquitylation of target proteins through linkage at K48 is the most thoroughly studied of the various ubiquitin chain linkages. It is now clear that many, if not all, poly-Ub chain topologies are likely to play distinct and important roles in regulating cellular processes. Nevertheless, K48 linkages remain a critical pathway for cells to maintain protein homeostasis and remain intriguing for the study of DUBs that play a role in regulating degradation, as well as the proteasome itself. These tetra-ubiquitin chains generated from the enzymatic linkage (E2-25K) of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for the lysine at position 48, limiting chain length.


Species Human
Source E. coli
Tag None
Molecular Weight 34,678.3 Da
Quantity 25 µg
Concentration Variable
Formulation 20 mM Tris pH 7.5, 150 mM NaCl, 1 mM EDTA
Storage -80°C, avoid freeze/thaw cycles

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  • Investigation of DUB linkage specificity.