SI4804: K48-Linked Tetra-Ubiquitin

Specifications

Poly-ubiquitylation of target proteins through linkage at K48 is the most thoroughly studied of the various ubiquitin chain linkages. It is now clear that many, if not all, poly-Ub chain topologies are likely to play distinct and important roles in regulating cellular processes. Nevertheless, K48 linkages remain a critical pathway for cells to maintain protein homeostasis and remain intriguing for the study of DUBs that play a role in regulating degradation, as well as the proteasome itself. These tetra-ubiquitin chains generated from the enzymatic linkage (E2-25K) of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for the lysine at position 48, limiting chain length.

Info