DB206: OTULIN

$232.00

In stock

SKU: DB-0206-0025 Category: Tags: ,

Specifications

Otulin (Gumby) is a deubiquitinase exhibiting high specificity for linear ubiquitin chains (M1). Its specific interactions with the proximal ubiquitin leads to the activation of the catalytic triad. Otulin binds to HOIP (RNF31), a component of the linear chain synthesizing E3 ligase complex called LUBAC and regulates its activity thus affecting NFκB-regulated pathways and proinflammatory responses.

Info

Species Human
Source
Tag
Molecular Weight 40.6 kDa
Quantity 25 µg
Concentration Variable
Formulation 20 mM Hepes pH 7.5, 100 mM NaCl, 5 mM 2-mercaptoethanol
Storage -80°C, avoid freeze/thaw cycles

Additional information

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