Specifications
USP14 (Ubiquitin Specific Protease 14) is a proteasome-associated deubiquitinase which releases ubiquitin from the proteasome-targeted ubiquitinated proteins. This enzyme serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded ER proteins via interaction with ERN1. It also plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation.
Info
| Species | Human |
| Source | E. coli |
| Tag | His6 + SUMO |
| Molecular Weight | 68 kDa |
| Quantity | 25 µg |
| Concentration | Variable |
| Formulation | |
| Storage | -80°C, avoid freeze/thaw cycles |
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