Specifications
Otulin (Gumby) is a deubiquitinase exhibiting high specificity for linear ubiquitin chains (M1). Its specific interactions with the proximal ubiquitin leads to the activation of the catalytic triad. Otulin binds to HOIP (RNF31), a component of the linear chain synthesizing E3 ligase complex called LUBAC and regulates its activity thus affecting NFκB-regulated pathways and proinflammatory responses.
Info
| Species | Human |
| Source | |
| Tag | |
| Molecular Weight | 40.6 kDa |
| Quantity | 25 µg |
| Concentration | Variable |
| Formulation | 20 mM Hepes pH 7.5, 100 mM NaCl, 5 mM 2-mercaptoethanol |
| Storage | -80°C, avoid freeze/thaw cycles |
Reviews
There are no reviews yet.