AMSH (Associated Molecule with the SH3-domain of STAM, STAM Binding Protein) is a JAMM domain-containing protein that functions as a deubiquitinase in vitro. AMSHcore contains only the core domain of AMSH protein. AMSH mediates the cleavage of K63-linked ubiquitin chains. This cleavage is enhanced in the presence of its binding partner STAM. AMSH plays a role in the regulation of the endosomal sorting of the epidermal growth factor receptor (EGFR).
|Molecular Weight||20.5 kDa|
|Formulation||50 mM Tris-HCl pH 8.0, 150 mM NaCl, 5 mM DTT, 10% glycerol|
|Storage||-80°C, avoid freeze/thaw cycles|