DB302: AMSHcore


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SKU: DB-0302-0025 Category:


AMSH (Associated Molecule with the SH3-domain of STAM, STAM Binding Protein) is a JAMM domain-containing protein that functions as a deubiquitinase in vitro. AMSHcore contains only the core domain of AMSH protein. AMSH mediates the cleavage of K63-linked ubiquitin chains. This cleavage is enhanced in the presence of its binding partner STAM. AMSH plays a role in the regulation of the endosomal sorting of the epidermal growth factor receptor (EGFR).


Species Human
Source E. coli
Tag His6
Molecular Weight 20.5 kDa
Quantity 25 µg
Concentration Variable
Formulation 50 mM Tris-HCl pH 8.0, 150 mM NaCl, 5 mM DTT, 10% glycerol
Storage -80°C, avoid freeze/thaw cycles

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  • This enzyme cleaves K63-linked ubiquitin chains in vitro