Specifications
Encoded by the PARK2 gene, the E3 ligase Parkin is part of the multi-protein E3 complex that encodes substrate proteins for degradation in the Ubiquitin-Proteosome Pathway. The precise function of this protein is unknown; however, mutations in this gene are known to cause a familial form of Parkinson’s disease known as autosomal recessive juvenile Parkinson’s disease (AR-JP). Parkin is described to be necessary for mitophagy (autophagy of mitochondria). Phosphorylation of Parkin’s UBL at Ser65 by PINK1 kinase activates Parkin.
Info
| Species | Human |
| Source | E. coli |
| Tag | His10-SUMO |
| Molecular Weight | 55 kDa |
| Quantity | 25 µg |
| Concentration | Variable |
| Formulation | 20 mM Tris pH 7.5, 150 mM NaCl, 10% Glycerol |
| Storage | -80°C, avoid freeze/thaw cycles |
Reviews
There are no reviews yet.