DB604: SARS-CoV-2 Papain-like Protease


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SKU: DB-0604-0100 Categories: , , Tags: , , ,


Within the last two decades, SARS and MERS coronaviruses emerged as global health concerns causing severe acute respiratory syndromes. In December 2019, a novel coronavirus (SARS-CoV-2) was identified in Wuhan, Hubei province in China. The SARS-CoV genome encodes several proteases including papain-like protease (PL2PRO; PLPro); this key enzyme along with 3CL-protease drives the early stage of infection by processing a large viral polypeptide into functional enzymes. SARS-CoV-2 PLPro shares 82% in protein sequence identity with PLPro from SARS-CoV. The SARS-CoV-2 PLPro was shown to have a deubiquitinating activity. Subsequently, it was shown that PLPro is also a deISGylase. PLPro cleaves ISG15 and Ubiquitin from synthetic substrates with high and low efficiency, respectively. PLPro represents an antiviral drug target for counteracting SARS-CoV-2 infections.


Species SARS-CoV-2
Source E. coli
Tag None
Molecular Weight 37 kDa
Quantity 100 µg
Concentration Variable
Formulation 50 mM Tris-HCl pH 8.5, 150 mM NaCl, 1 mM DTT, 10% glycerol
Storage -80°C, avoid freeze/thaw cycles

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  • In Vitro PLPro Inhibitor Screening
  • Active in the Ub-Rhodamine, Ub-CHOP and ISG15-CHOP assay.

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