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SI9639: LDN-57444, DUB inhibitor

LifeSensors SI9639 is a potent, selective inhibitor of USP7 deubiquitinase, used in research to study protein regulation and cancer therapy development.

$182.00$591.00

  • Inhibition of ubiquitin C-terminal hydrolase
  • Cell biology
  • Drug discovery
  • Benefits: cell-permeable
LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 µM) with approximately 28-fold greater selectivity over UCH-L3. Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration.

Info

Purity > 98% (TLC); NMR (Conforms)
Quantity 10 mg, 50 mg
Molecular Weight 397.6 Da
Physical State Yellow powder
Solubility DMSO (20 mg/mL)
CAS No. 668467-91-2
Storage 4°C, (-20°C Long term). Store solutions at -20°C for up to one week. Protect from light. The product can be shipped at room temperature.
  • Inhibition of ubiquitin C-terminal hydrolase
  • Cell biology
  • Drug discovery
  • Benefits: cell-permeable

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