Specifications
K63 chains traditionally play a role in intracellular signaling, trafficking, and autophagy. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. K63 Di-Ubiquitin (phosphorylated) is a dimeric chain of wild-type ubiquitin, wherein ubiquitin monomers are linked together via an isopeptide bond between Lysine 63 and the C-terminal Glycine. The chains are then enzymatically phosphorylated at the Ser65 position.
Info
Species | Human |
Source | E. coli |
Tag | None |
Molecular Weight | 17219-17299 Da (depending on degree of phosphorylation) |
Quantity | Variable |
Concentration | Variable |
Formulation | 20 mM Tris pH 7.5, 150 mM NaCl |
Storage | -80°C, avoid freeze/thaw cycles |
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