SI1102P: K11-Linked Di-Ubiquitin (Phosphorylated)

$695.00

Specifications

K11-linked ubiquitination is traditionally associated with cell cycle regulation and proteasomal degradation. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. K11 Di-Ubiquitin (phosphorylated) is a dimeric chain of wild-type ubiquitin, wherein ubiquitin monomers are enzymatically linked together via an isopeptide bond between Lysine 11 and the C-terminal Glycine. The chains are then enzymatically phosphorylated at the Ser65 position.

Info

Species Human
Source E. coli
Tag None
Molecular Weight 17219-17299 Da (depending on degree of phosphorylation)
Quantity Variable
Concentration Variable
Formulation 20 mM Tris pH 7.5, 150 mM NaCl
Storage -80°C, avoid freeze/thaw cycles

Additional information

SKU

SI-01102P-0100

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• Investigation of phosphoubiquitin chain specificity and selectivity
• Studies on the role of phosphoubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
• Analysis of phosphoubiquitin-mediated signaling pathways and cellular responses
• Structural studies to elucidate the architecture and dynamics of phosphoubiquitin chains
• Screening assays to identify modulators of phosphoubiquitin chain assembly and disassembly processes