Encoded by the PARK2 gene, the E3 ligase Parkin is part of the multi-protein E3 complex that encodes substrate proteins for degredation in the Ubiquitin-Proteosome Pathway. The precise function of this protein is unknown; however, mutations in this gene are known to cause a familial form of Parkinson’s disease known as autosomal recessive juvenile Parkinson’s disease (AR-JP). Parkin is described to be necessary for mitophagy (autophagy of mitochondria).
|Molecular Weight||64 kDa|
|Storage||-80°C, avoid freeze/thaw cycles|