SI0104P: M1 (linear) Tetra-Ubiquitin (Phosphorylated)

LifeSensors’ SI0104P: M1 (linear) Tetra-Ubiquitin (Phosphorylated) is a phosphorylated linear tetra-ubiquitin reagent ideal for studying phosphorylation-dependent ubiquitin signaling and related cellular pathways

$695.00

M1-linked ubiquitination is traditionally associated with regulation of NFĸB and IFN signaling. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. M1 Tetra-Ubiquitin (phosphorylated) is a tetrameric chain of wild-type ubiquitin. It is expressed as a linear chain wherein monomers are linked through N-terminal methionines and C-terminal glycines. The chains are then enzymatically phosphorylated at the Ser65 position. Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	34697-34937 Da (depending on degree of phosphorylation)
Quantity	25µg
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Investigation of phospho-ubiquitin chain specificity and selectivity
Studies on the role of phospho-ubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
Analysis of phospho-ubiquitin-mediated signaling pathways and cellular responses
Structural studies to elucidate the architecture and dynamics of phospho-ubiquitin chains
Screening assays to identify modulators of phospho-ubiquitin chain assembly and disassembly processes

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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SI0104P: M1 (linear) Tetra-Ubiquitin (Phosphorylated)

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