SI0104P: M1 (linear) Tetra-Ubiquitin (Phosphorylated)

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Specifications

M1-linked ubiquitination is traditionally associated with regulation of NFĸB and IFN signaling. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways.M1 Tetra-Ubiquitin (phosphorylated) is a tetrameric chain of wild-type ubiquitin. It is expressed as a linear chain wherein monomers are linked through N-terminal methionines and C-terminal glycines. The chains are then enzymatically phosphorylated at the Ser65 position.

Info

Species Human
Source E. coli
Tag None
Molecular Weight 34697-34937 Da (depending on degree of phosphorylation)
Quantity Variable
Concentration Variable
Formulation 20 mM Tris pH 7.5, 150 mM NaCl
Storage -80°C, avoid freeze/thaw cycles

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  • Investigation of phosphoubiquitin chain specificity and selectivity
  • Studies on the role of phosphoubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
  • Analysis of phosphoubiquitin-mediated signaling pathways and cellular responses
  • Structural studies to elucidate the architecture and dynamics of phosphoubiquitin chains
  • Screening assays to identify modulators of phosphoubiquitin chain assembly and disassembly processes