AB602: PLPro Antibody

Specifications

Within the last two decades, SARS and MERS coronaviruses emerged as global health concerns causing severe acute respiratory syndromes. In December 2019, a novel coronavirus (SARS-CoV-2) was identified in Wuhan, Hubei province in China. The SARS-CoV genome encodes several proteases including papain-like protease 1 (PLP1; PLPro); this key enzyme along with 3CL-protease and PLP2 (PLPro2) drives the early stage of infection by processing a large viral polypeptide into functional enzymes. SARS-CoV PLPro shares 82% identity with PLPro from SARS-CoV-2. Therefore, this antibody targeting SARS-CoV PLPro is a valuable diagnostic tool for PLPro expressed by SARS CoV-2.

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