USP14 is a ubiquitin specific protease that associates with the proteasome. This association with the proteasome has been shown to enhance the enzymatic activity of the proteasome. Recent studies have demonstrated that USP14 expression in certain cancers correlates with metastasis. Using a chemical probe researchers have shown that USP14 can interact with ISG15, a ubiquitin-like protein.
|Molecular weight||68 kDa (With tags)|
|Storage||Store at -80°C, avoiding repeated freeze-thaw cycles.|
|Alternative Names||Deubiquitinating enzyme 14, TGT, Ubiquitin carboxyl-terminal hydrolase 14, Ubiquitin-specific-processing protease 14, Ubiquitin thioesterase 14|
|Expression Host||E. coli|