Specifications
K11-linked ubiquitination is traditionally associated with cell cycle regulation and proteasomal degradation. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. K11 Di-Ubiquitin (phosphorylated) is a dimeric chain of wild-type ubiquitin, wherein ubiquitin monomers are enzymatically linked together via an isopeptide bond between Lysine 11 and the C-terminal Glycine. The chains are then enzymatically phosphorylated at the Ser65 position.
Info
| Species | Human |
| Source | E. coli |
| Tag | None |
| Molecular Weight | 17219-17299 Da (depending on degree of phosphorylation) |
| Quantity | Variable |
| Concentration | Variable |
| Formulation | 20 mM Tris pH 7.5, 150 mM NaCl |
| Storage | -80°C, avoid freeze/thaw cycles |
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