SI0102-5µg (panel) Linear (Ub2) di-ubiquitin

SI0103P: M1 (linear) Tri-Ubiquitin (Phosphorylated)

LifeSensors SI0103P is a phosphorylated M1 (linear) Tri-Ubiquitin, ideal for studying ubiquitin chain formation, signaling pathways, and protein regulation in cells.

$595.00

Product Advantages

• Investigation of phosphoubiquitin chain specificity and selectivity
• Studies on the role of phosphoubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
• Analysis of phosphoubiquitin-mediated signaling pathways and cellular responses
• Structural studies to elucidate the architecture and dynamics of phosphoubiquitin chains
• Screening assays to identify modulators of phosphoubiquitin chain assembly and disassembly processes

M1-linked ubiquitination is traditionally associated with regulation of NFĸB and IFN signaling. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways.M1 Tri-Ubiquitin (phosphorylated) is a trimeric chain of wild-type ubiquitin. It is expressed as a linear chain wherein monomers are linked through N-terminal methionines and C-terminal glycines. The chains are then enzymatically phosphorylated at the Ser65 position. Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	26281-26361 Da (depending on degree of phosphorylation)
Quantity	Variable
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl
Storage	-80°C, avoid freeze/thaw cycles