Schematic representation of the SARS-CoV-2 structure.

DB602: PLPro

$95.00

In stock

Specifications

Within the last two decades, SARS and MERS coronaviruses emerged as global health concerns causing severe acute respiratory syndromes. In December 2019, a novel coronavirus (SARS-CoV-2) was identified in Wuhan, Hubei province in China. The SARS-CoV genome encodes several proteases including papain-like protease 1 (PLP1; PLPro); this key enzyme along with 3CL-protease and PLP2 (PLPro2) drives the early stage of infection by processing a large viral polypeptide into functional enzymes. SARS-CoV PLPro shares 82% in protein sequence identity with PLPro from SARS-CoV-2. Initially, it was reported that SARS PLPro was a deubiquitinase, however subsequent work has shown that PLPro is preferentially a deISGylase. PLPro cleaves ISG15-PLA2 and Ub-PLA2 with high and low efficiency, respectively. The PLPro represents an antiviral drug target for counteracting of SARS-CoV and MERS-CoV infections.

Info

Species SARS-CoV
Source E. coli
Tag His6
Molecular Weight 35 kDa
Quantity 25 µg
Concentration Variable
Formulation
Storage -80°C, avoid freeze/thaw cycles

Additional information

SKU

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Applications

  • This enzyme is active in the Ub-Rhodamine, Ub-CHOP and ISG15-CHOP assay.