SI6304T: K63-Linked Tetra-Ubiquitin, TAMRA-labeled

SKU SI-6304-T025 Categories Ubiquitin Chains, Ubiquitin Chains and Derivatives

LifeSensors SI6304T is a TAMRA-labeled K63-linked tetra-ubiquitin used for studying ubiquitin signaling, protein modification, and proteasome pathways in research and drug discovery.

$805.00

In stock

Poly-ubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. Modification of proteins by K63-linked poly-ubiquitination has been implicated in, among other cellular processes, the regulation of the DNA damage response, endosomal sorting, autophagy of misfolded/aggregated proteins, neurodegeneration, and signal transduction. These tetra-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 63. The most distal ubiquitin contains an arginine substitution for a lysine at position 63, limiting chain length. The TAMRA moiety is attached to a single, non-lysine site in the proximal ubiquitin.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	34,802.0 Da
Quantity	25 µg
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl, 1 mM EDTA
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Optimization of pull-down conditions for K48 TUBE and K63-TUBE reagents.

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All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

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All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

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All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

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SI6304T: K63-Linked Tetra-Ubiquitin, TAMRA-labeled

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