Phospho K6 Di-Ubiquitin

SKU SI-0612P-0050 Categories All, Ubiquitin and Neuro-degeneration, Ubiquitin Chains, Ubiquitin Chains and Derivatives Tag Degradation

Product Advantages

Application

Invitro experiments related to activation of Parkin and PINK1.
Biomarker discovery for Parkinson’s disease.
Invitro models for understanding role of pSer65UB in pathogenesis of PD.

Mitophagy (the autophagic processing of damaged mitochondria) via Parkin activation is mainly promoted by K6 and K63 linked chains. K6-linked ubiquitination is also a main contributor to the DNA damage response and acts as a DNA-binding enhancer during the innate immune system response. These chain types are also involved in protein stabilization and other non-degradative processes. These di-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 6. The K6 di-ubiquitin is then phosphorylated via enzymatic reaction with Tribolium castaneum PINK1 kinase (PTEN-induced kinase 1) at Ser 65.

Product Information

Purity	≥ 80% by SDS-PAGE
Molecular Weight	17192 Da
Physical State	Liquid
Quantity	50 µg
Solubility	>30 mg/ml
Storage	-80°C, avoid freeze/thaw cycles

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