Neurodegeneration is a slow and progressive loss of neuronal cells which ultimately involve cell death. In Parkinson’s disease (PD) and Alzheimer’s disease (AD) accumulation of aggregated proteins and defective mitochondria leads to neuronal cell death. The ubiquitin proteasome system (UPS) and autophagy-lysosomal pathway (ALP) plays a key role in neurodegenerative diseases. Targeted degradation of aggregated proteins and damaged mitochondria are predicted to be neuroprotective and offer transformative therapies for PD and AD.
LifeSensors has developed several tools, innovative technologies, and knowledge solutions for advancing research in the field of neurodegeneration. For example, Parkin E3 ligase is a master regulator of mitochondrial health and is implicated in both PD and AD. Lifesensors has developed unique HTS (High-Throughput System) assays for discovering Parkin modulators. Lifesensors is also developing novel biomarkers for PD and AD.