The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol
protease belonging to the C12 family of peptidases that hydrolyze peptide bonds
at the C-terminal glycine of ubiquitin. So far UCHL1 has been shown to be
specifically expressed in neuronal and neuroendocrine tissues within humans.
Mutations to this gene are associated with Parkinson’s disease.