Explore the frontiers of biology to make breakthrough discoveries with applications in drug discovery and diagnostics? Ubiquitin Proteasome System (UPS) provides a challenge as a new wave of drugs are emerging, such as PROtein TArgeting Chimeras (PROTACs) and Molecular Glues that target undruggable space. Senior Scientists are expected to develop innovative technologies to understand the role of ubiquitin in cell physiology. Our technologies are used worldwide by academic, pharma and biotech companies. The Senior Scientist will lead research programs to develop innovative technologies, execute drug discovery projects for our clients, as well as drive the development of new products and product applications. They will write scientific articles, patents, and present data at national and international meetings.
Competency in multiple aspects of drug discovery with focus on designing and executing a variety of cell based and biochemical assays.
Proven track record in cloning, cell culture, protein expression, purification, and characterization.
Proficient in biochemical and immunological assays (ELISA, SPR, WB, FACS, etc.)
Independent experimental design and execution, analytical problem-solving capabilities.
Ability to stay on top of the latest scientific research related targeted protein degradation (TPD) field, with commitment to deep knowledge in project specific biology.
Prior experience with PROTACs and molecular glues for protein degradation is preferred.
PhD in biological sciences
3-10+ years of laboratory experience in an academic or industrial setting
Experience in molecular cloning and designing expression vectors
Experience in protein expression, purification, and protein engineering
Knowledge of mass spec and biophysical techniques to study protein structure and function
Experience in assay development and HTS
Knowledge of the ubiquitin proteasome pathway is desirable
Ability to work in a highly entrepreneurial environment
Write scholarly papers, patents and provide intellectual leadership for the company
Proven interpersonal skills and the ability to work as a team
In addition to competitive salary, we offer an attractive benefits package which includes, medical, dental, and vision coverage, FSA, 401K with a company match, generous PTO policy, and life insurance programs.
PROTAC IS A REGISTERED TRADEMARK OF ARVINAS OPERATIONS, INC., AND IS USED UNDER LICENSE.
Our business development team works with customers to develop simple and cost effective work plans. We facilitate a smooth transfer of our technology, offering transfer and licensing terms that fit the needs of the client’s laboratory and organization. Our team is dedicated to providing state-of-the-art products to help put your research and development efforts into the forefront. We’ve developed non-traditional approaches and scalable discounts to bring our technology to your lab.