Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

UB401: PINK1

LifeSensors UB401 is recombinant PINK1 from Tribolium castaneum, a serine/threonine kinase that phosphorylates Parkin and ubiquitin, crucial for mitochondrial quality control and Parkinson’s research

$309.00

In stock

In stock

PTEN-induced putative kinase protein 1 (Serine/Threonine kinase PINK1) is an important protein that saves the dysfunction of mitochondria upon application of cellular stress. When the mitochondria is depolarized, PINK stabilizes and gets accumulated. When E3 Ubiquitin Ligase Parkin (PARK2) is brought to the damaged mitochondria, it is activated by PINK1 by phosphorylation at Ser 65 which in turn interacts with ubiquitin that is also phosphorylated at Ser 65. This process is important for removing the damaged mitochondria by mitophagy (selective autophagy) by mediating activation and translocation of PARK2. Recombinant human PINK1 effectively phosphorylates recombinant Parkin, mono-Ubiquitin, and poly-Ubiquitin chains. It specifically phosphorylates both Parkin and Ubiquitin at serine 65. This recombinant protein contains an MBP tag.

Info

Species T. castaneum (red flour beetle)
Source E. coli
Tag MBP
Molecular Weight 106 kDa
Quantity 50 µg
Concentration Variable
Formulation
Storage -80°C, avoid freeze/thaw cycles

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

Available Monday – Friday, 9:00 AM – 5:00 PM EST
We typically respond within 24 hours

Visit Anytime

271 Great Valley Parkway Malvern, PA 19355

Send us a Message

Have a question about our solutions? We’d love to hear from you.
* Required fields

More from This Category

LifeSensors' SI0103 is a high-purity Linear Tri-Ubiquitin chain used for studying ubiquitin signaling, deubiquitylase activity, and protein interactions....
LifeSensors' SI0602 is K6-linked Di-Ubiquitin, a key biomolecule involved in mitophagy and DNA damage response, used for advanced biochemical research....
LifeSensors NS106 is a high-quality reagent designed for precise detection and analysis of ubiquitin linkages, supporting advanced research in protein....
LifeSensors NS102 monitor offers accurate EtCO2 and SpO2 monitoring with PureSAT® and MedAir™ tech, featuring a widescreen touch display and....

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Menu

Learning Center