DUBTACs or deubiquitinase-targeting chimeras, are opposite to PROTACs. DUBTACs are bifunctional molecules designed to recruit deubiquitinase enzymes to specific target proteins for removing ubiquitin and thereby stabilizing proteins. DUBTAC mediated protein stabilization is a novel therapeutic modality. LifeSensors technology provides advanced tools and assays to investigate the mechanisms and efficacy of DUBTACs, enabling precise characterization and optimization of these novel compounds for therapeutic development and research purposes.
- DUBTACs recruit DUBs to a target protein and remove ubiquitin chains, resulting in stabilization of target proteins
- DUBTACs consist of three components:
- DUB recruiter ligand
- Target protein binder
- Linker connecting both entities
Lifesensors offers unique and physiologically relevant DUB assays that allows rapid characterization of DUB recruiter ligands for their specificity and potency.
DUBTACs restore protein levels, function, and rescue target proteins from degradation via the proteasome. LifeSensors helps you study these DUBs and DUBTACs to make breakthrough discoveries and pave the way to novel therapeutics.