SI0102-5µg (panel) Linear (Ub2) di-ubiquitin

SI1104P: K11-Linked Tetra-Ubiquitin (Phosphorylated)

LifeSensors SI1104P: K11-Linked Tetra-Ubiquitin (Phosphorylated) for advanced research in ubiquitin signaling, proteasomal degradation, and cellular pathway analysis.

$795.00

Product Advantages

Investigation of phosphoubiquitin chain specificity and selectivity
Studies on the role of phosphoubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
Analysis of phosphoubiquitin-mediated signaling pathways and cellular responses
Structural studies to elucidate the architecture and dynamics of phosphoubiquitin chains

K11-linked ubiquitination is traditionally associated with cell cycle regulation and proteasomal degradation. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. K11 Tetra-Ubiquitin (phosphorylated) is a tetrameric chain of wild-type ubiquitin, wherein ubiquitin monomers are enzymatically linked together via an isopeptide bond between Lysine 11 and the C-terminal Glycine. The chains are then enzymatically phosphorylated at the Ser65 position.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	34313-34937 Da (depending on degree of phosphorylation)
Quantity	Variable
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl
Storage	-80°C, avoid freeze/thaw cycles

Document 1

Document 1

Investigation of phosphoubiquitin chain specificity and selectivity
Studies on the role of phosphoubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
Analysis of phosphoubiquitin-mediated signaling pathways and cellular responses
Structural studies to elucidate the architecture and dynamics of phosphoubiquitin chains