USA, Pennsylvania, Malvern

Explore the frontiers of biology to make breakthrough discoveries with applications in drug discovery and diagnostics? Ubiquitin Proteasome System (UPS) provides a challenge as a new wave of drugs are emerging, such as PROtein TArgeting Chimeras (PROTACs) and Molecular Glues that target undruggable space. Senior Scientists are expected to develop innovative technologies to understand the role of ubiquitin in cell physiology. Our technologies are used worldwide by academic, pharma and biotech companies. The Senior Scientist will lead research programs to develop innovative technologies, execute drug discovery projects for our clients, as well as drive development of new technologies and their applications drug discovery and diagnostics. They will write scientific articles, patents, and present data at national and international meetings.

Responsibilities:

• Competency in multiple aspects of drug discovery with focus on designing and executing a variety of cell based and biochemical assays.


• Understanding of protein structure, modeling using alpha fold and AI techniques to understand protein: protein and protein small molecule interactions.


• Proven track record in cloning, cell culture, protein expression, purification, and characterization.


• Proficient in biochemical and immunological assays (ELISA, SPR, WB, FACS, etc.).


• Independent experimental design and execution, analytical problem-solving capabilities.


• Ability to stay on top of the latest scientific research related to targeted protein degradation (TPD) field, with commitment to deep knowledge in project specific biology.

• PhD in biological sciences.


• 0-10+ years of laboratory experience in an academic or industrial setting.


• Experience in structural biology is an advantage.


• Experience in molecular cloning and designing expression vectors.


• Experience in protein expression, purification, and protein engineering.


• Knowledge of mass spec and biophysical techniques to study protein structure and function.


• Experience in assay development and HTS.


• Knowledge of the ubiquitin proteasome pathway is desirable.


• Ability to work in a highly entrepreneurial environment.


• Write scholarly papers, patents and provide intellectual leadership for the company.


• Proven interpersonal skills and the ability to work as a team.