LifeSensors is a proud sponsor of the EMBO Ubiquitin Workshop in Cavtat, Croatia from September 13-17, 2019! This workshop is important to the Ubiquitin community to inspire further progress and collaboration.
Read More
LIFESENSORS ATTENDS BIO CONVENTION 2019 IN PHILADELPHIA The Bio International Convention will be in Philadelphia from June 3-6, 2019. More than 16,000 biotech and pharmaceutical leaders will attend and network to explore...
Read More
Lewy Body Dementia (LBD) is a debilitating neurodegenerative disease that is increasingly becoming a public health concern. “In Lewy body dementia, alpha-synuclein forms into clumps inside neurons, starting in areas…
The Cold Spring Harbor Laboratory will be hosting a conference on the Ubiquitin Proteasome System (UPS) and associated Diseases April 23rd-27th. LifeSensors will be presenting on our most recent developments…
LifeSensors has spent years supporting the drug discovery efforts in Ubiquitin Proteasome System (UPS) research. We are excited to see this growing area of research gain more attention through conferences…
ABSTRACT Ubiquitin-Proteasome system (UPS), along with chaperone mediated-autophagy (CMA) and macroautophagy, constitutes the protein quality control system of the cell. The failure of these systems is particularly difficult to...
Read More
SEE THE LIFESENSORS PRESENTATION ON NOVEL PROTAC ASSAYS HERE. PLEASE CONTACT US FOR MORE INFORMATION ON THIS EXCITING TECHNOLOGY- BD@LIFESENSORS.COM
Read More
By: Mark Tingey, Katelyn Roberts, and Meredith Paterson Parkinson’s disease is often referred to as a silent disease. It often begins in very innocuous ways, small ticks and behaviors that…
LIFESENSORS TO SPONSOR DISCOVERY ON TARGET To help further scientific advancement in the field of ubiquitin, LifeSensors has partnered with CHI to assist with their Discovery on Target conference this…
LifeSensors Scientists Apurva Chaturvedi, Peter Foote, Li Liang, Dominic Vasturia, and Rajesh Singh recently presented research at FASEB in SnowMass, Colorado. A downloadable PDF of this poster can be found...
Read More
UCHL1 The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol protease belonging to the C12 family of peptidases that hydrolyze peptide bonds at the C-terminal glycine of…
USP14 USP14 is a ubiquitin specific protease that associates with the proteasome. This association with the proteasome has been shown to enhance the enzymatic activity of the proteasome. Recent studies…
USP8 USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is involved in the commitment to lysosomal sorting. Additional research has shown that USP8 plays a…
E6-AP E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a…
ITCH ITCH is a HECT E3, which influences immunity, the skin, and plays a role in cancer by targeting various transcription factors and growth factors. Additionally, ITCH functions by ubiquitinylating…
NEDD4 Nedd4 is an inner membrane bound HECT E3 that promotes endocytosis of sodium channels marked for degradation at FGFR1 receptors, with K63 linked ubiquitin selectivity. Nedd4 has also been…
CHIP CHIP is an E3 that coordinates with Ataxin3 to mark misfolded chaperone proteins for UPS degradation. Deficiencies within this pathway are associated with rare disease, such as Spinocerebellar Ataxia,…
TAU PROTEINS PDB ID: 5D2V Within healthy neurons, tau proteins are responsible for stabilizing microtubules within the cell. Unfortunately, in instances associated with neurodegenerative disease these proteins are found to…
PARKIN PDB ID: 5C1Z Parkin is an E3 ligase, which ubiquitinylates proteins for degradation within neurons, and is primarily associated with mitophagy. By tagging damaged proteins with ubiquitin, the neuron…
PARIS (ZNF746) Recently found to have drastic implications in Parkinson’s, researchers have shown PARIS to be a key regulating factor of neuronal death within the substantia nigra (the major site…
Β-AMYLOID PDB ID: 38KC Amyloid precursor proteins (APP), present in the fatty membrane of neuronal cells, undergo a series of enzymatic cleavages to create smaller proteins known as β-Amyloid. Sometimes,…
PINK1 PDB ID: 50AT PTEN induced putative kinase 1 (PINK1) is important in the role of mitophagy, once it accumulates on the outer membrane of a damaged mitochondria, it summons…
Α-SYNUCLEIN PDB ID: 1XQ8 α-Synuclein is mainly found in the brain and is present at the presynaptic terminal of neurons. Although its function in a healthy brain is currently unknown,…
PROTEIN PROFILES MARK TINGEY, DOMINIC VASTURIA, AND KATIE SHEETS Next in its series of educational posts, LifeSensors is proud to discuss the role the proteins play in neurodegenerative diseases. This...
Read More
LifeSensors is a leader in Ubiquitin Proteasome System (UPS) drug discovery technologies and SUMO Platform for Difficult to Express Proteins. We are pleased to inform you that members of our...
Read More
PRESS RELEASE MAY 29, 2018 271 GREAT VALLEY PARKWAY MALVERN, PA 19355 LifeSensors Announces New Distribution Agreement with AmyJet in China LifeSensors Inc, a Biotech and Drug Discovery Company is…
LIFESENSORS IS PROUD TO SPONSOR THE 2018 FUSION UBIQUITIN CONFERENCE IN NASSAU, BAHAMAS It is with great pride that LifeSensors announces its sponsorship of the 2018 Fusion Conference The Ubiquitin…
Current Paradigms and Innovative Research Dear Colleagues, Alzheimer’s and Parkinson’s diseases are the silent killers. Despite a massive investment, the failure rate in drug development is 99.6%. The largest hurdle…
Dear Colleagues, Deciphering the Ubiquitin Code is the first step in utilizing the Ubiquitin Proteasome System (UPS) to drug the so-called undruggable targets. LifeSensors is proud to present a new…
UBIQUITIN: HOPE FOR THE FUTURE OF ALZHEIMER’S RESEARCH by: Mark Tingey and Peter Foote Uncle Walt stared at us, not recognizing us or remembering our names. His eyes, which were…
WE HAVE DEVELOPED A NEW WEBSITE FOR CUSTOMERS TO FOLLOW OUR INNOVATIONS AND THE FUTURE OF MEDICINE BY EXPLORING THE UBIQUITIN AND SUMO PATHWAY CHECK OUT OUR NEW FEATURES LIFESENSORS…
LifeSensors recently presented the work of Rajesh Singh, Cari Sagum, Jianji Chen, Apurva Chaturvedi, Peter Foote, and Mark Bedford at Cold Spring Harbor Laboratories. A PDF of this poster can...
Read More
Lifesensors recently presented the work of Peter Foote, Xialong Lu, Apurva Chaturvedi, and Rajesh Singh at AACR2018. A PDF of this poster can be downloaded here. ABSTRACT Ubiquitylation is a versatile...
Read More
LifeSensors' Scientists Apurva Chaturvedi, Peter Foote, Dominic Vasturia, and Rajesh Singh recently presented their research at AACR2018. A pdf of this poster can be downloaded here. ABSTRACT Purpose of study: The work...
Read More