[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text]LifeSensors is a proud sponsor of the EMBO Ubiquitin Workshop in Cavtat, Croatia from September 13-17, 2019! This workshop is important to the Ubiquitin community to inspire further progress and collaboration. [/vc_column_text][/vc_column][/vc_row]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] LIFESENSORS ATTENDS BIO CONVENTION 2019 IN PHILADELPHIA The Bio International Convention will be in Philadelphia from June 3-6, 2019. More than 16,000 biotech and pharmaceutical leaders will attend and network to explore new opportunities […]
Lewy Body Dementia (LBD) is a debilitating neurodegenerative disease that is increasingly becoming a public health concern. “In Lewy body dementia, alpha-synuclein forms into clumps inside neurons, starting in areas of the brain that control aspects of memory and movement. This process causes neurons to work less effectively and, eventually, to die.” Currently, 1 in […]
The Cold Spring Harbor Laboratory will be hosting a conference on the Ubiquitin Proteasome System (UPS) and associated Diseases April 23rd-27th. LifeSensors will be presenting on our most recent developments in ubiquitin technology that will impact the field of ubiquitin research. The list of attendees already features many of the leaders in the field. We […]
LifeSensors has spent years supporting the drug discovery efforts in Ubiquitin Proteasome System (UPS) research. We are excited to see this growing area of research gain more attention through conferences like this. We believe PROTACs and other modulators of the UPS will make profound impacts in the clinic, on a variety of “undruggable” targets. LifeSensors […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] ABSTRACT Ubiquitin-Proteasome system (UPS), along with chaperone mediated-autophagy (CMA) and macroautophagy, constitutes the protein quality control system of the cell. The failure of these systems is particularly difficult to overcome in […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text]SEE THE LIFESENSORS PRESENTATION ON NOVEL PROTAC ASSAYS HERE. PLEASE CONTACT US FOR MORE INFORMATION ON THIS EXCITING TECHNOLOGY- BD@LIFESENSORS.COM[/vc_column_text][/vc_column][/vc_row]
By: Mark Tingey, Katelyn Roberts, and Meredith Paterson Parkinson’s disease is often referred to as a silent disease. It often begins in very innocuous ways, small ticks and behaviors that are almost imperceptible. This is how it began with Alan Alda. In a recent interview, he explained that he first suspected something was amiss when […]
LIFESENSORS TO SPONSOR DISCOVERY ON TARGET To help further scientific advancement in the field of ubiquitin, LifeSensors has partnered with CHI to assist with their Discovery on Target conference this September in Boston. This event will provide unique insight into the state of the field, and how we as scientists can work together to resolve […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] LifeSensors Scientists Apurva Chaturvedi, Peter Foote, Li Liang, Dominic Vasturia, and Rajesh Singh recently presented research at FASEB in SnowMass, Colorado. A downloadable PDF of this poster can be found here. […]
UCHL1 The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol protease belonging to the C12 family of peptidases that hydrolyze peptide bonds at the C-terminal glycine of ubiquitin. So far UCHL1 has been shown to be specifically expressed in neuronal and neuroendocrine tissues within humans. Mutations to this gene are associated with […]
USP14 USP14 is a ubiquitin specific protease that associates with the proteasome. This association with the proteasome has been shown to enhance the enzymatic activity of the proteasome. Recent studies have demonstrated that USP14 expression in certain cancers correlates with metastasis. Using a chemical probe researchers have shown that USP14 can interact with ISG15, a […]
USP8 USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is involved in the commitment to lysosomal sorting. Additional research has shown that USP8 plays a critical role in the stability of receptor tyrosine kinases. USP8 has been demonstrated to regulate the stability of Nrdp1, a E3 ubiquitin ligase. Among USP8’s […]
E6-AP E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a HECT domain E3 containing an active site cysteine which accepts a charged ubiquitin from the ubiquitin-E2 thiolester complex. E6-AP has been linked to a neurodevelopmental […]
ITCH ITCH is a HECT E3, which influences immunity, the skin, and plays a role in cancer by targeting various transcription factors and growth factors. Additionally, ITCH functions by ubiquitinylating target substrates for lysosomal degradation, and is associated with K29, K48, and K63 liked ubiquitin. Due to ITCH’s regulator effects on specific transcription and growth […]
NEDD4 Nedd4 is an inner membrane bound HECT E3 that promotes endocytosis of sodium channels marked for degradation at FGFR1 receptors, with K63 linked ubiquitin selectivity. Nedd4 has also been shown to regulate dendritic proliferation and branching during neuronal development. It has also been experimentally demonstrated that Nedd4 is phosphorylated for activation by SRC (Parkin-like). […]
CHIP CHIP is an E3 that coordinates with Ataxin3 to mark misfolded chaperone proteins for UPS degradation. Deficiencies within this pathway are associated with rare disease, such as Spinocerebellar Ataxia, Autosomal Recessive 16 and Gordon Holmes Syndrome.
TAU PROTEINS PDB ID: 5D2V Within healthy neurons, tau proteins are responsible for stabilizing microtubules within the cell. Unfortunately, in instances associated with neurodegenerative disease these proteins are found to aggregate and form bulk tangles within the neuron, leading to a flawed network of neuronal communication and ultimately neuronal degradation. This neurodegeneration is believed to […]
PARKIN PDB ID: 5C1Z Parkin is an E3 ligase, which ubiquitinylates proteins for degradation within neurons, and is primarily associated with mitophagy. By tagging damaged proteins with ubiquitin, the neuron is able to sequester harmful proteins for degradation, perpetuating the lifecycle of the neuron. Research has shown in the absence, or downregulation of Parkin neuronal […]
PARIS (ZNF746) Recently found to have drastic implications in Parkinson’s, researchers have shown PARIS to be a key regulating factor of neuronal death within the substantia nigra (the major site of neuronal degradation within the limbic system). In the absence of Parkin, PARIS is free of ubiquitin and carries out the role of repressing transcription […]
Β-AMYLOID PDB ID: 38KC Amyloid precursor proteins (APP), present in the fatty membrane of neuronal cells, undergo a series of enzymatic cleavages to create smaller proteins known as β-Amyloid. Sometimes, β-Amyloid may be overproduced leading to an accumulation of this protein. The extra β-Amyloid sticks together and creates plaques in neuronal cells. These plaques are […]
PINK1 PDB ID: 50AT PTEN induced putative kinase 1 (PINK1) is important in the role of mitophagy, once it accumulates on the outer membrane of a damaged mitochondria, it summons PARKIN to begin the process of selective autophagy. Together, PINK1 and PARKIN work to control the quality of mitochondrias. If PINK1 is mutated, PARKIN may […]
Α-SYNUCLEIN PDB ID: 1XQ8 α-Synuclein is mainly found in the brain and is present at the presynaptic terminal of neurons. Although its function in a healthy brain is currently unknown, α-Synuclein is believed to take part in maintaining synaptic ventricles as well as regulating the neurotransmitter, dopamine. α-Synuclein is a protein of interest for Parkinson’s […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] PROTEIN PROFILES MARK TINGEY, DOMINIC VASTURIA, AND KATIE SHEETS Next in its series of educational posts, LifeSensors is proud to discuss the role the proteins play in neurodegenerative diseases. This series of […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text]LifeSensors is a leader in Ubiquitin Proteasome System (UPS) drug discovery technologies and SUMO Platform for Difficult to Express Proteins. We are pleased to inform you that members of our team will be […]
PRESS RELEASE MAY 29, 2018 271 GREAT VALLEY PARKWAY MALVERN, PA 19355 LifeSensors Announces New Distribution Agreement with AmyJet in China LifeSensors Inc, a Biotech and Drug Discovery Company is pleased to announce our new partnership with Chinese distributor AmyJet Scientific. AmyJet Scientific Inc. was established in 2010 in Wuhan, Hubei Province, Tongi, Kowloon. As […]
LIFESENSORS IS PROUD TO SPONSOR THE 2018 FUSION UBIQUITIN CONFERENCE IN NASSAU, BAHAMAS It is with great pride that LifeSensors announces its sponsorship of the 2018 Fusion Conference The Ubiquitin System: Function, Physiology, and its role in Disease. Rather than focusing on structural elements of ubiquitin, this conference will be dedicated to the function of […]
Current Paradigms and Innovative Research Dear Colleagues, Alzheimer’s and Parkinson’s diseases are the silent killers. Despite a massive investment, the failure rate in drug development is 99.6%. The largest hurdle in developing a radical therapy for Alzheimer’s disease (AD) and Parkinson’s Disease (PD) is a lack of a simple diagnostic blood test. Current diagnostics are […]
Dear Colleagues, Deciphering the Ubiquitin Code is the first step in utilizing the Ubiquitin Proteasome System (UPS) to drug the so-called undruggable targets. LifeSensors is proud to present a new technology which will allow for much more precise and accurate targeting of the UPS. The new K48 TUBE HF was developed to show enhanced selectivity […]
UBIQUITIN: HOPE FOR THE FUTURE OF ALZHEIMER’S RESEARCH by: Mark Tingey and Peter Foote Uncle Walt stared at us, not recognizing us or remembering our names. His eyes, which were once bright and filled with curiosity, were now fearful and withdrawn. He appeared to crumple in upon himself, as if the world he no longer […]
WE HAVE DEVELOPED A NEW WEBSITE FOR CUSTOMERS TO FOLLOW OUR INNOVATIONS AND THE FUTURE OF MEDICINE BY EXPLORING THE UBIQUITIN AND SUMO PATHWAY CHECK OUT OUR NEW FEATURES LIFESENSORS HAS DEVELOPED A DRUG DISCOVERY PLATFORM TO TAP INTO THE MOST INNOVATIVE DRUG TARGETS FROM THE UBIQUITIN PROTEASOME SYSTEM (UPS). WE ARE YOUR PARTNERS, FROM […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] LifeSensors recently presented the work of Rajesh Singh, Cari Sagum, Jianji Chen, Apurva Chaturvedi, Peter Foote, and Mark Bedford at Cold Spring Harbor Laboratories. A PDF of this poster can be downloaded Here. […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text]Lifesensors recently presented the work of Peter Foote, Xialong Lu, Apurva Chaturvedi, and Rajesh Singh at AACR2018. A PDF of this poster can be downloaded here. ABSTRACT Ubiquitylation is a versatile post-translational modification involved […]
[vc_row type=”in_container” full_screen_row_position=”middle” scene_position=”center” text_color=”dark” text_align=”left” overlay_strength=”0.3″ shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_link_target=”_self” column_shadow=”none” column_border_radius=”none” width=”1/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text] LifeSensors’ Scientists Apurva Chaturvedi, Peter Foote, Dominic Vasturia, and Rajesh Singh recently presented their research at AACR2018. A pdf of this poster can be downloaded here. ABSTRACT Purpose of study: The work presented here […]
