UB307: Hrd1 (Synoviolin)

LifeSensors UB307 is a recombinant Hrd1 (Synoviolin) E3 ubiquitin ligase involved in ER-associated degradation (ERAD) and linked to rheumatoid arthritis research.

$462.00

In stock

Product Advantages

Hrd1 is a RING domain E3 ligase that is involved in the conjugation of ubiquitin to target substrates. Hrd1 has been demonstrated to function with the E2 enzymes UBE2D3 (UbcH5c) and UBE2G2 in vitro. Hrd1 is an ER-associated ligase involved in ERAD and has been linked to rheumatoid arthritis. It is present in human rheumatoid synovial cells and found to be a causative factor for arthropathy in in vivo studies. Hrd1 is also found in brain neurons and its proper regulation may be linked to neurodegenerative diseases. This construct is a Hrd1 N-terminal deletion containing residues 236-617 consisting of the complete C-terminal cytoplasmic portion. The N-terminal transmembrane spanning portion has been deleted. This Hrd1 N-terminal deletion mutant is active as an E3 ligase containing the RING and substrate recognition domains. Hrd1 is currently made-to-order and requires a 2-3 week lead time.

Info

Species	Human
Source	E. coli
Tag	His₆-SUMO
Molecular Weight	Cytoplasmic fragment (236-617): 39.3 kDa (without SUMO tag)
Quantity	25 μg
Concentration	Variable
Formulation
Storage	-80°C, avoid freeze/thaw cycles