UB302: CARP2

SKU UB-0302-0025 Categories E3 Ubiquitin Ligases, Ubiquitin Chains and Derivatives Tag E3 ligase

LifeSensors UB302 (CARP2) is a specialized ubiquitin-binding protein used in research to study ubiquitin signaling and protein regulation pathways with high specificity.

$529.00

In stock

CARP2 (caspase 8/10 associated RING protein 2) is a RING-domain E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates, along with E1 and E2 enzymes. CARPs (CARP1 and CARP2, 77% identity) also belong to the IAP family (inhibitors of apoptosis proteins) inhibiting activation of DED (death effector domain) containing caspase proteins (8 and 10). In addition to targeting caspases 8 and 10, CARPs have been shown to target phosphorylated p53 for degradation in an Hdm2 independent manner. Furthermore, CARP2 has been shown to be a negative regulator of TNF induced NF-κB activation by targeting RIP for degradation.

Info

Species	Human
Source	E. coli
Tag	His₆-SUMO
Molecular Weight	41 kDa
Quantity	25 µg
Concentration	Variable
Formulation
Storage	-80°C, avoid freeze/thaw cycles

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UB302: CARP2

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