Questions about a product, technology or experimental design? Give us a call 610-644-8845. For special institutional pricing, check out our Distributors!
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

UB223H: UBE2W, His6

LifeSensors UB223H is a His6-tagged UBE2W E2 ubiquitin-conjugating enzyme, essential for studying ubiquitination pathways and protein regulation in research.

Price range: $189.00 through $375.00

UBE2W is a ubiquitin conjugating enzyme that mediates the transfer of ubiquitin from a ubiquitin-activating enzyme (E1) to a substrate protein or E3 ligase. UBE2W was originally identified as the human homolog of the Arabidopsis E2 enzyme Ubc-16. Researchers demonstrated that UBE2W contains a NLS sequence and is localized to the nucleus of HEK293 cells. UBE2W binds to the E3 ligase BRCA1 and mediates the monoubiquitylation of BRCA12. In vitro UBE2W catalyzes monoubiquitination and ‘Lys-11’-linked polyubiquitination.

Info

Species Human
Source E. coli
Tag His6
Molecular Weight 18,456 Da
Quantity 0.8 nmol, 3.0 nmol
Concentration 40µM
Formulation TBS, 10% glycerol
Storage -80°C, avoid freeze/thaw cycles

Applications

  • Identify cognate E2/E3 pairs
  • Characterize upregulation/downregulation of E2 enzymes
  • Build poly-ubiquitin chains
  • Characterize ubiquitin chain specificity of E2 enzymes
  • Analyze expression of E2 enzymes

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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