UB222: UBE2C (Ubc10)

LifeSensors UB222 (UBE2C/Ubc10) is an E2 ubiquitin conjugating enzyme essential for protein ubiquitylation, playing a key role in targeted protein degradation pathways.

$196.00 – $390.00

SKU UB-0222 Categories E2 Ubiquitin Conjugating Enzymes, Ubiquitin Ligases and Enzymes

Product Advantages

Applications

Identify cognate E2/E3 pairs
Characterize upregulation/downregulation of E2 enzymes
Build poly-ubiquitin chains
Characterize ubiquitin chain specificity of E2 enzymes
Analyze expression of E2 enzymes

Benefits

Untagged (native) E2 conjugation enzyme

UBE2C (also known as Ubc10) is an E2 conjugation enzyme that is involved in the ubiquitylation of target substrates, along with E1 and E3 enzymes. UBE2C interacts with the Anaphase Promoting Complex (APC) and, as a member of this complex, functions to ubiquitylate substrates and target these substrates, which include several cyclins, for degradation. As such, UBE2C plays a critical role in cell cycle progression and has recently been shown to play a key role in tumorigenesis.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	19,652.6 Da
Quantity	0.8 nmol, 3.0 nmol
Concentration	40 µM
Formulation	25 mM Tris pH 7.4, 150 mM NaCl, 10 mM DTT, 10% glycerol
Storage	-80°C, avoid freeze/thaw cycles