Questions about a product, technology or experimental design? Give us a call 610-644-8845. For special institutional pricing, check out our Distributors!
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

UB220: UBE2V2 (MMS2, UEV-2)

LifeSensors UB220 (UBE2V2/MMS2/UEV-2) is an ubiquitin E2 variant protein that forms complexes with E2 enzymes, crucial for studying ubiquitin signaling and protein regulation.

Price range: $196.00 through $390.00

UBE2V2 (also known as MMS2 or UEV-2) is an ubiquitin E2 variant (UEV) protein that forms a heterodimeric complex with the E2 conjugating enzyme UBE2N. This complex is responsible for ubiquitylation of target substrates along with E1 and E3 enzymes. The UBE2N/UBE2V2 complex assembles K63-linked polyubiquitin chains that are utilized in non-degradative ubiquitin signaling pathways (DNA repair, signal transduction). The UEV proteins are structurally similar to E2 enzymes displaying the same fold, but lack the active site cysteine of the E2. The UBE2N/UBE2V2 complex is unique in that it is has the ability to form free K63-linked polyubiquitin chains in solution in the absence of an E3 ligase.

Info

Species Human
Source E. coli
Tag None
Molecular Weight 16,363.1 Da
Quantity 0.8 nmol, 3.0 nmol
Concentration 40 µM
Formulation 25 mM Tris pH 7.4, 150 mM NaCl, 10 mM DTT, 10% glycerol
Storage -80°C, avoid freeze/thaw cycles
  • Identify cognate E2/E3 pairs
  • Characterize upregulation/downregulation of E2 enzymes
  • Build poly-ubiquitin chains
  • Characterize ubiquitin chain specificity of E2 enzymes
  • Analyze expression of E2 enzymes

Benefits

  • Untagged (native) E2 conjugation enzyme

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

Available Monday – Friday, 9:00 AM – 5:00 PM EST
We typically respond within 24 hours

Visit Anytime

271 Great Valley Parkway Malvern, PA 19355

Send us a Message

Have a question about our solutions? We’d love to hear from you.
* Required fields

More from This Category

LifeSensors UB227 is a human UBE2G2 enzyme involved in endoplasmic reticulum-associated degradation (ERAD), essential for studying protein ubiquitination and degradation....
LifeSensors UB219 is the UBE2T enzyme essential for the Fanconi anemia pathway, mediating ubiquitin transfer for protein regulation and DNA....
LifeSensors UB209: UBE2R2 (Ubc3B) is an E2 ubiquitin-conjugating enzyme, similar to UBC3/CDC34. It participates in the ubiquitylation pathway, with....
LifeSensors UB208H is a His6-tagged UBE2R1 (CDC34) E2 ubiquitin-conjugating enzyme that regulates cellular proliferation by controlling p27/Kip1 protein levels, useful....

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Menu

Learning Center