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UPS Inhibitor

SI9880: SMER3

LifeSensors SI9880 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SCFMET30, used in research to modulate protein degradation and ubiquitin pathways.

$250.00 – $1,246.00

Product Advantages

Applications

Cell-based or in vitro inhibition of SCFMET30

Small Molecule Enhancer of Rapamycin 3 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SCFMET30. SMER3 binds directly to the F-box subunit Met30 and blocks binding to the SCF core complex. This inhibitor is cell permeable. Significant inhibition is typically seen at 30-100 μM.

Info

Purity	>98% (TLC), NMR (conforms)
Quantity	10 mg, 25 mg, 50 mg
Molecular Weight	224.2 Da
Physical State	Yellow powder
Solubility	DMSO (20mg/ml), requires heating
CAS No.	67200-34-4
Storage	4°C, (-20°C Long term). Store solutions at -20 °C for up to 2 months. The product can be shipped at room temperature.

Document 1

Document 1

Applications

Cell-based or in vitro inhibition of SCFMET30

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