Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9880: SMER3

LifeSensors SI9880 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SCFMET30, used in research to modulate protein degradation and ubiquitin pathways.

Price range: $250.00 through $1,246.00

Small Molecule Enhancer of Rapamycin 3 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SCFMET30. SMER3 binds directly to the F-box subunit Met30 and blocks binding to the SCF core complex. This inhibitor is cell permeable. Significant inhibition is typically seen at 30-100 ÎĽM.

Info

Purity >98% (TLC), NMR (conforms)
Quantity 10 mg, 25 mg, 50 mg
Molecular Weight 224.2 g/mol, alternative Daltons
Physical State Yellow powder
Solubility DMSO (20mg/ml), requires heating
CAS No. 67200-34-4
Storage 4°C, (-20°C Long term). Store solutions at -20 °C for up to 2 months. The product can be shipped at room temperature.

Applications

  • Cell-based or in vitro inhibition of SCFMET30

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

Available Monday – Friday, 9:00 AM – 5:00 PM EST
We typically respond within 24 hours

Visit Anytime

271 Great Valley Parkway Malvern, PA 19355

Send us a Message

Have a question about our solutions? We’d love to hear from you.
* Required fields

More from This Category

LifeSensors SI9890 (AT-406) is an oral Smac mimetic that inhibits apoptosis proteins XIAP, cIAP1, and cIAP2, showing potential in cancer....
LifeSensors SI9885 (PRT-4165) is a potent inhibitor of histone H2A ubiquitylation, targeting RNF2 and Ring1A in polycomb repressive complex 1....
LifeSensors SI9845 (SKPin C1) is a selective inhibitor of Skp2-mediated p27 degradation, inducing p27 accumulation and cell cycle arrest, used....
LifeSensors SI9830 (MLN4924) is a potent, selective substrate-assisted inhibitor of NEDD8-activating enzyme (NAE), used to block neddylation and study protein....

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Menu

Learning Center