SI9840: TAME HCl

Inhibits the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) by inhibiting binding and activation by the APC activators Cdc20 and Cdh1. TAME inhibits cyclin proteolysis in Xenopus extracts (IC₅₀ = 12 µM) and inhibits Cdc20 association with APC at 200 µM. It stabilizes cyclin B1 by prematurely terminating ubiquitination. Substrate for trypsin, thrombin, plasmin, and other proteases.

Info

Purity	>98% (TLC); NMR (Conforms)
Quantity	100 mg
Molecular Weight	378.9 Da
Physical State	White Powder
Solubility	May be dissolved in DMSO (35 mg/mL); or water (35 mg/mL)
CAS No.	1784-03-8
Storage	4°C, (-20°C Long term). The product can be shipped at room temperature.