SI9752: NMS-873

SKU SI-9752-0005 Categories p97 Inhibitors, Small Molecule Modulators and PROTACs

LifeSensors SI9752 (NMS-873) is an allosteric inhibitor targeting ATPase activity of AAA+ proteins, blocking protein extraction from the ER, used in advanced cellular research.

$250.00

In stock

p97 (aka VCP, Cdc48) is intimately involved in the ERAD process through the retrotranslocation of misfolded proteins targeted for degradation by the proteasome. It is a homohexamer of AAA+ ATPase subunits and ATP hydrolysis is required for protein extraction from the ER. NMS-873 is an allosteric inhibitor of ATPase activity, binding to the D1 and D2 domains of adjacent subunits (Magnaghi, D’Alessio et al. 2013). NMS-873 is reported to have an IC50 for p97 of 20-30nM.

Info

Purity	99% (TLC), NMR(conforms)
Quantity	5 mg
Molecular Weight	520.67 Da
Physical State	Powder
Solubility	192mM in DMSO
CAS No.	1418013-75-8
Storage	4°C, (-20°C Long term). The product can be shipped at room temperature.

Datasheet

Applications

Inhibition of ERAD

Induction of apoptosis in cancer cells

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SI9752: NMS-873

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