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SI9752: NMS-873

LifeSensors SI9752 (NMS-873) is an allosteric inhibitor targeting ATPase activity of AAA+ proteins, blocking protein extraction from the ER, used in advanced cellular research.

$250.00

SKU SI-9752-0005 Categories p97 Inhibitors, Small Molecule Modulators and PROTACs

In stock

Product Advantages

Applications

Inhibition of ERAD

Induction of apoptosis in cancer cells

p97 (aka VCP, Cdc48) is intimately involved in the ERAD process through the retrotranslocation of misfolded proteins targeted for degradation by the proteasome. It is a homohexamer of AAA+ ATPase subunits and ATP hydrolysis is required for protein extraction from the ER. NMS-873 is an allosteric inhibitor of ATPase activity, binding to the D1 and D2 domains of adjacent subunits (Magnaghi, D’Alessio et al. 2013). NMS-873 is reported to have an IC50 for p97 of 20-30nM.

Info

Purity	99% (TLC), NMR(conforms)
Quantity	5 mg
Molecular Weight	520.67 Da
Physical State	Powder
Solubility	192mM in DMSO
CAS No.	1418013-75-8
Storage	4°C, (-20°C Long term). The product can be shipped at room temperature.

Datasheet

Datasheet

Applications

Inhibition of ERAD

Induction of apoptosis in cancer cells

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