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UPS Inhibitor

SI9750: DBeQ

LifeSensors SI9750 (DBeQ) is a potent, selective, reversible cell-permeable inhibitor of AAA-ATPase p97, with Ki=3.2 µM, used in cellular activity and protein degradation studies.

$250.00 – $505.00

SKU SI-9750 Categories ,

Applications

  • To study ubiquitin-dependent and the endoplasmic reticulum-associated degradation pathway (p97 ATPase)
  • Cell biology

 

DBeQ is a cell-permeable, potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks both ubiquitin-dependent and endoplasmic reticulum-associated degradation pathways, protein clearance pathways, and activates caspases -3 and -7 inducing apoptosis.

Info

Purity > 98% (TLC), NMR (Conforms)
Quantity 10 mg, 25 mg
Molecular Weight 340.4 Da
Physical State Yellow powder
Solubility DMSO (25mg/ml)
CAS No. 177355-84-9
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

No documents available.

No documents available.

Applications

  • To study ubiquitin-dependent and the endoplasmic reticulum-associated degradation pathway (p97 ATPase)
  • Cell biology

 

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