SI9740: Celastrol

LifeSensors SI9740 is a specialized phospho-ubiquitin chain derivative designed for advanced research in ubiquitin signaling and protein regulation pathways.

$171.00 – $541.00

SKU SI-9740 Categories Proteasome Inhibitors, Small Molecule Modulators and PROTACs

Product Advantages

Applications

Inhibition of NF-kappa-B-dependent pathways and inhibition of 20S proteasome chymotrypsin-like activity
Cell biology
Drug discovery
Benefits: cell-permeable

Celastrol is a naturally occurring triterpenoid antioxidant compound with anti-inflammatory activity. Inhibits NFκB (IC50 = 270 nM). It induces heat shock response and cytoprotection in various cells. Celastrol inhibits 20S proteasome chymotrypsin-like activity (IC50 = 2.5 μM). Cell permeable.

Info

Purity	> 98% (TLC), NMR (Conforms)
Quantity	10 mg, 50 mg
Molecular Weight	450.6 Da
Physical State	Red powder
Solubility	DMSO (45mg/mL); Ethanol (30mg/mL)
CAS No.	34157-83-0
Storage	4°C, (-20°C Long term). The product can be shipped at room temperature.

Datasheet

Datasheet

Applications

Inhibition of NF-kappa-B-dependent pathways and inhibition of 20S proteasome chymotrypsin-like activity
Cell biology
Drug discovery
Benefits: cell-permeable