Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9715: MLN9708

LifeSensors SI9715 is a specialized phospho-ubiquitin chain derivative designed to support advanced research in protein regulation and ubiquitin signaling pathways.

$370.00

In stock

In stock

MLN9708 is a proteasome inhibitor. Much like Bortezomib, the active form of MLN9708 selectively and reversibly inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome, with IC50 and Ki of 3.4 nM and 0.93 nM, respectively. MLN9708 is the prodrug form of MLN2238; the two compounds are also known as ixazomib citrate and ixazomib, respectively. Under physiological conditions, the boronic citrate ester is rapidly hydrolyzed to a boronic acid. Ixazomib has been used in combination therapy as a treatment for multiple myeloma, and studies indicate that it has the potential to treat other cancers as well.

Info

Purity >99.6 (HPLC), NMR (conforms)
Quantity 5 mg
Molecular Weight 517.12 Da
Physical State Lyophilized powder
Solubility DMSO (103 mg/mL)
CAS No. 1201902-80-8
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

Applications

  • Inhibition of chymotrypsin-like proteasome catalytic activity.
  • Cellular studies of proteasome inhibition.

 

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

Available Monday – Friday, 9:00 AM – 5:00 PM EST
We typically respond within 24 hours

Visit Anytime

271 Great Valley Parkway Malvern, PA 19355

Send us a Message

Have a question about our solutions? We’d love to hear from you.
* Required fields

More from This Category

LifeSensors SI9735 (Oprozomid/ONX912) is a clinical-stage proteasome inhibitor selectively targeting 20S proteasome β5/LMP7 with potent IC50 values of 36 nM/82....
LifeSensors SI9740 is a specialized phospho-ubiquitin chain derivative designed for advanced research in ubiquitin signaling and protein regulation pathways.....
LifeSensors AC2007 (Brefeldin A) is a cell-permeable lactone antibiotic that inhibits ATPase, disrupting protein transport and modulating autophagy in cellular....
LifeSensors SI9810 (PYR-41) is a cell-permeable, irreversible inhibitor of ubiquitin-activating enzyme E1, with IC50 < 10 µM, used in research....

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Menu

Learning Center