Specifications
Spautin 1 inhibits USP10 and USP13 with IC50’s of 0.6 μM and 0.7 μM, respectively. These deubiquitylases target the Beclin-1 subunit and promote degradation of Vps34-PI3 kinase complexes. Its effect on autophagy is Beclin-independent. Spautin induces apoptosis of cancer cells under starvation conditions.
Info
| Purity | ≥98% (TLC), NMR (conforms) |
| Quantity | 5 mg |
| Molecular Weight | 271.3 Da |
| Physical State | Tan colored powder |
| Solubility | DMSO (50mg/mL) |
| CAS No. | 126288-28-7 |
| Storage | 4°C, (-20°C long term). The product can be shipped at room temperature. |
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