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SI9644: Spautin 1

LifeSensors SI9644 is a potent, selective inhibitor of USP7 deubiquitinase, used in research to study protein regulation and cancer therapy development.

$122.00

SKU SI-9644-0005 Categories DUB inhibitors, Small Molecule Modulators and PROTACs

In stock

Product Advantages

Applications

USP10/USP13 inhibition

Inhibition of autophagy

Benefits: cell-permeable

Spautin 1 inhibits USP10 and USP13 with IC50’s of 0.6 μM and 0.7 μM, respectively. These deubiquitylases target the Beclin-1 subunit and promote degradation of Vps34-PI3 kinase complexes. Its effect on autophagy is Beclin-independent. Spautin induces apoptosis of cancer cells under starvation conditions.

Info

Purity	≥98% (TLC), NMR (conforms)
Quantity	5 mg
Molecular Weight	271.3 Da
Physical State	Tan colored powder
Solubility	DMSO (50mg/mL)
CAS No.	126288-28-7
Storage	4°C, (-20°C long term). The product can be shipped at room temperature.

Datasheet

Datasheet

Applications

USP10/USP13 inhibition

Inhibition of autophagy

Benefits: cell-permeable

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