Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9644: Spautin 1

LifeSensors SI9644 is a potent, selective inhibitor of USP7 deubiquitinase, used in research to study protein regulation and cancer therapy development.

$122.00

In stock

In stock

Spautin 1 inhibits USP10 and USP13 with IC50’s of 0.6 μM and 0.7 μM, respectively. These deubiquitylases target the Beclin-1 subunit and promote degradation of Vps34-PI3 kinase complexes. Its effect on autophagy is Beclin-independent. Spautin induces apoptosis of cancer cells under starvation conditions.

Info

Purity ≥98% (TLC), NMR (conforms)
Quantity 5 mg
Molecular Weight 271.3 Da
Physical State Tan colored powder
Solubility DMSO (50mg/mL)
CAS No. 126288-28-7
Storage 4°C, (-20°C long term). The product can be shipped at room temperature.

Applications

  • USP10/USP13 inhibition
  • Inhibition of autophagy
  • Benefits: cell-permeable

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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