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SI9634: ML323

LifeSensors SI9634 is a specialized ubiquitin reagent designed for advanced protein research, enabling precise studies of ubiquitin signaling and protein regulation.

$233.00

In stock

Applications

  • Studying the role of USP1-UAF1 in DNA-damage repair.
  • Sensitization of cells to cisplatin-killing.
ML323 binds to the complex of USP1-UAF1 resulting in the inhibition of USP1 deubiquitylase activity (Liang, Dexheimer et al. 2014). The IC50 is reported to be 76 nM against Ub-Rho110 and 174 nM against K63-linked diubiquitin. Inhibition is reversible and exhibits mixed-mode kinetics. ML323 showed little or no inhibitory activity against a collection of DUBs including USPs 2, 5, 7, 8, 10, 11, 14, and 21, UCH-L1 and UCH-L3, and SenP1.

Info

 
Purity >98% (TLC), NMR (Conforms)
Quantity 5 mg
Molecular Weight 384.48 Da
Physical State Powder
Solubility DMSO (198 mM)
CAS No. 1572414-83-5
Storage 4 °C, (-25°C long term). The product can be shipped at room temperature.

Applications

  • Studying the role of USP1-UAF1 in DNA-damage repair.
  • Sensitization of cells to cisplatin-killing.

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