Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI9634: ML323

LifeSensors SI9634 is a specialized ubiquitin reagent designed for advanced protein research, enabling precise studies of ubiquitin signaling and protein regulation.

$233.00

In stock

In stock

ML323 binds to the complex of USP1-UAF1 resulting in the inhibition of USP1 deubiquitylase activity (Liang, Dexheimer et al. 2014). The IC50 is reported to be 76 nM against Ub-Rho110 and 174 nM against K63-linked diubiquitin. Inhibition is reversible and exhibits mixed-mode kinetics. ML323 showed little or no inhibitory activity against a collection of DUBs including USPs 2, 5, 7, 8, 10, 11, 14, and 21, UCH-L1 and UCH-L3, and SenP1.

Info

 
Purity >98% (TLC), NMR (Conforms)
Quantity 5 mg
Molecular Weight 384.48 Da
Physical State Powder
Solubility DMSO (198 mM)
CAS No. 1572414-83-5
Storage 4 °C, (-25°C long term). The product can be shipped at room temperature.

Applications

  • Studying the role of USP1-UAF1 in DNA-damage repair.
  • Sensitization of cells to cisplatin-killing.

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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