Questions about a product, technology or experimental design? Give us a call 610-644-8845. For special institutional pricing, check out our Distributors!
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

AC2007: Brefeldin A

LifeSensors AC2007 (Brefeldin A) is a cell-permeable lactone antibiotic that inhibits ATPase, disrupting protein transport and modulating autophagy in cellular studies

Price range: $108.00 through $609.00

Brefeldin A is a cell permeable fermentation product from Penicillium brefeldianum. It is a lactone antibiotic and ATPase inhibitor for protein transport with an IC50 of 0.2 μM in HCT 116 cells. Brefeldin A has been widely used as specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. It blocks secretion and prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Brefeldin A also inhibits guanine nucleotide-exchange proteins BIG1 and BIG2, activators of ADP-ribosylation factors. It induces apoptosis independently of p53 and  activates sphingomyelin metabolism.

Info

Purity >99.0% by HPLC
Quantity 5mg, 25mg, 50mg
Molecular Weight 280.4 g/mol
Physical State Lyophilized powder
Solubility 100 mg/mL in DMSO; or 25 mg/ml in warm ethanol
CAS No. 20350-15-6
Storage -20°C, avoid freeze/thaw cycles

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

Available Monday – Friday, 9:00 AM – 5:00 PM EST
We typically respond within 24 hours

Visit Anytime

271 Great Valley Parkway Malvern, PA 19355

Send us a Message

Have a question about our solutions? We’d love to hear from you.
* Required fields

More from This Category

LifeSensors SI9720 is a specialized reagent for ubiquitin-proteasome research, aiding drug discovery with high-quality assays and protein analysis tools.....
LifeSensors AC1005 is a high-precision physiological pressure signal conditioner using fiber optic technology, ideal for accurate, real-time biomedical pressure monitoring.....
LifeSensors SI9699 is a potent, cell-permeable inhibitor targeting deubiquitinases, aiding research in protein regulation and degradation with high efficacy.....
LifeSensors SI9639 is a potent, selective inhibitor of USP7 deubiquitinase, used in research to study protein regulation and cancer therapy....

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Menu

Learning Center